Right out of the box you will have to deal with the following five frustrations when running Vista:

1	File browsing interface is broken. When you browse for a file using the new file browsing interface it actually displays, in the dropdown men, a selection of website instead of the usual folder tree that once allowed you to browse all the way to the drives, desktop, etc. The new interface makes it very tedious to go back to the parent directory as Microsoft remove the traditional Back button.
2	The new start menu leaves much to be desired for. In some ways the new start menu of Windows Vista is an upgrade in that it categorizes your applications in a better manner and gives you better control over them. However that's only helpful for those users with a hundred or so programs downloaded to your computer. Many casual users rarely hit the thirty mark. Previously using Windows Explorer if you want a specific folder to launch you simply type it out and the folder will appear or the application will run. Windows Vista has overcomplicated this process drastically. Now if you forget the trailing backslash it will launch a program that it feels is the closest match to that word. For example when you type in C: and accidentally hit Enter it will launch the Remote Desktop. If you have a great many programs, applications or files stored on your computer the new version of Windows start menu brought to us by Vista may prove to be valuable to you, however, for the majority of PC users the Vista start menu is not an upgrade.
3	Windows Networking on Vista is very confusing. If you have a mobile life that functions around a PC, laptop or other wireless device you will want to be very cautious of Windows Vista. As every place you use your wireless laptop or mobile device requires a different networking connection (static IP, dynamic IP, etc.) you'll get very use to seeing the following screen: Windows Networking on Vista actually manages to provide far too many options and expects the end user to know the differences of each. If you have never used Vista before or you are not a networking consultant you'll find it a struggle to track down how to change your IP address on your wireless card.
4	Windows Vista search is broken. Windows search utility on Windows XP Service Pack 2 was well known to have its fair share of flaws and oftentimes convinced you that a file was missing when it actually wasn't. Instead of fixing this problem in Vista, Microsoft simply removed this feature all together. Vista does not provide you with a simple search utility allowing you to search for any string of text or letters to find your documents, text files, photos, etc. You can now only search for specific documents such as Excel or Word. In order to perform a complete search of your hard drive you will actually have to go to a command line and perform a wildcard directory search to get better results.
5	Windows copying still has not improved. Vista boasts a sleeker look with a cooler progress bar but still suffers the same weaknesses. Half way into copying your folder of hundreds or photos or files it will stall and stop because one file could not be opened. This also makes larger installations of applications extremely tedious and tends to lock up quite frequently. You'll find the same problems when you start copying to a remote file share folder (online or over a network) and all of Explorer locks up. It's sad but true and the problem still has not been fixed in Vista.